Macrophage-MSCs Interplay in Orthodontic Bone Remodelling: Mechanics-Immunity-Stem Cell Axis
Mingzhu Chen, Yanjie Li, Jiangtian Hu · 2026
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Description
Mingzhu Chen, Yanjie Li, and Jiangtian Hu review how immune cells and stem cells jointly steer bone remodeling during orthodontic treatment. Braces push teeth through bone, and the bone must be eaten away on one side and rebuilt on the other. Two cell types run this balance: macrophages, which switch from an inflammatory mode to a healing mode under force, and local mesenchymal stem cells. Each side steers the other through vesicles and chemical signals, forming a loop, the mechanics-immunity-stem cell axis.
Signals pass along a few main pathways, covering bone building, bone removal, and the macrophage switch itself. Other immune cells, including neutrophils and T cells, tune the environment. This crosstalk offers targets for add-on therapies that speed remodeling. Faster remodeling could shorten treatment, a goal patients and clinicians share. The review maps where drugs or materials might intervene.
Catalog record
| CREATOR | Mingzhu Chen, Yanjie Li, Jiangtian Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |