Bidirectional Mendelian Randomization and Single‑Cell RNA Sequencing Reveal an NK Cell–Mediated Causal Link Between Endometriosis and Endometrial Cancer
Zijie An, Yanqing Gong, Xuedan Deng, Yong Xie · 2026
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Description
Zijie An and co-authors hunted for a causal link between two womb diseases in a 2026 study. Endometriosis, where womb-lining tissue grows outside the womb, shares many traits with endometrial cancer. Whether one helps cause the other, and through which cells, was unclear.
The team joined two methods. Gene-based causal tests weighed the arrow in both directions, and single-cell gene reads profiled tissue from patients with each disease. Natural killer cells stood out as a go-between in the link. Their subsets and talk with other cells shifted in both diseases. The joint proof gives a fresh lead for care that calms the shared path.
Catalog record
| CREATOR | Zijie An, Yanqing Gong, Xuedan Deng, Yong Xie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |