CircCDK6 Regulates Stemness Maintenance and Cisplatin Resistance in Lung Adenocarcinoma via the Wnt/β-Catenin Signaling Pathway
Dan Li, Yanwei Shen, Li Wang, Huan Sun, Yuan Wang · 2026
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Description
Li and co-authors study a circular RNA called circCDK6 in lung adenocarcinoma, a common form of lung cancer. They ask whether circCDK6 helps cancer stem cells persist and resist the drug cisplatin. The team measured circCDK6 levels in several cancer cell lines. They then raised or lowered its levels and tested drug response with cell growth and colony assays. A mouse tumor model tested the effect in living tissue.
CircCDK6 levels were highest in the H1299 and H1975 cell lines. Raising circCDK6 boosted stem cell markers and made cells harder to kill with cisplatin. Lowering it had the reverse effect. The work links circCDK6 to the Wnt and beta-catenin pathway and names it a possible drug target.
Catalog record
| CREATOR | Dan Li, Yanwei Shen, Li Wang, Huan Sun, Yuan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |