Pharmaceutical development of composition of effervescent tablets with acetylsalicylic acid, paracetamol, and ascorbic acid
Oksana Panysheva · 2026
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Description
Oksana Panysheva develops a fizzy tablet that combines three familiar pain and cold remedies, in a study published in 2026. The tablet carries aspirin at 300 milligrams, paracetamol at 200, and ascorbic acid at 300, aimed at the Ukrainian market. Effervescent products must dissolve fast, taste acceptable, and stay stable, so each ingredient in the mix has to earn its place.
Using dispersion and regression analysis, Panysheva screened fillers, disintegrants, and lubricants for direct compression, scoring twelve quality indicators from powder flow to tablet hardness and fizz time. The best acid-to-base balance for the fizz reaction came out at a ratio of 1 to 1.312. A binder-and-filler pairing proved decisive for hardness with quick disintegration, and the final formula adds chosen sweeteners and flavorings.
Catalog record
| CREATOR | Oksana Panysheva |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |