Dysregulation of the glycolysis–mitochondrial metabolism axis in osteoarthritis: mechanisms and therapeutic implications
Ren Zhang, Su-Zhen Chen, Shang-Chun Guo, Shi-Cong Tao · 2026
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Description
Ren Zhang and co-authors frame osteoarthritis as a fuel-system failure inside cartilage cells in a 2026 review. The disease grinds down joints in over five hundred ninety-five million people. Cartilage cells are odd: they lean heavily on glycolysis, splitting sugar without oxygen, instead of the mitochondrial burning most cells prefer, and that balance must stay tightly tuned.
The review welds the two fuel routes into one axis: sugar splitting in the cell body, burning in the mitochondria, and joint decay at the end. When the axis slips, energy falters, waste builds, and cartilage loses its upkeep. The authors gather the mechanisms behind the slip, then point to candidate markers and drug targets along the axis. Their pitch is dual-target therapy: fix both fuel routes at once rather than either alone.
Catalog record
| CREATOR | Ren Zhang, Su-Zhen Chen, Shang-Chun Guo, Shi-Cong Tao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |