Current and emerging antibacterial strategies for periprosthetic joint infection: An overview
Marco Fosca, Veronica Manescu, Iulian Antoniac, Julietta V. Rau · 2026
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Description
Infection around an artificial joint is among the worst outcomes of joint replacement, because germs seal themselves in biofilms on the implant. Marco Fosca, Veronica Manescu, Iulian Antoniac, and Julietta Rau survey the countermeasures in a 2026 review. The paper covers two decades of work, from 2003 to 2025.
The search found 300 records, and 138 studies passed screening: lab tests, animal work, and clinical trials. The review follows the care pathway and weighs the standard tool, antibiotic-loaded bone cement, against resorbable depots, gels, coatings, nanomaterials, and newer antibiofilm agents. Germs that resist many drugs make local delivery attractive, since doses can be high at the implant and low elsewhere. The authors sort what is proven in patients from what still lives in the lab.
Catalog record
| CREATOR | Marco Fosca, Veronica Manescu, Iulian Antoniac, Julietta V. Rau |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 324 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |