A synergistic nanozyme platform breaking the neuroinflammatory-oxidative stress cycle for extended pain relief
Chengfeng Zhang, Zihan Xue, Jingyi Wang, Jianing Li, Wanlong Qian, Xueting Wang, Yong-Jing Gao, Zhongping Chen, Faming Wang, Yan Zhang · 2026
Read A synergistic nanozyme platform breaking the neuroinflammatory-oxidative stress cycle for extended pain relief by Chengfeng Zhang, Zihan Xue, Jingyi Wang, Jianing Li, Wanlong Qian, Xueting Wang, Yong-Jing Gao, Zhongping Chen, Faming Wang, Yan Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13185767.txt.
Description
Chengfeng Zhang and co-authors build a nanoparticle treatment meant to break the cycle that keeps chronic pain going. Their 2026 study targets the loop between nerve inflammation and oxidative stress in the spinal cord and brain. The platform packs selenium-doped carbon dots, which act as artificial enzymes, plus a plant anti-inflammatory compound into fat bubbles called liposomes.
In cell tests the particles neutralized harmful reactive species and calmed overactive immune cells of the nervous system. A single dose eased inflammatory pain in mice for up to three days, far longer than a standard shot. The treatment also helped in nerve injury and chemotherapy pain models. Safety tests looked clean. The authors pitch the platform as a long-acting option for chronic pain care.
Catalog record
| CREATOR | Chengfeng Zhang, Zihan Xue, Jingyi Wang, Jianing Li, Wanlong Qian, Xueting Wang, Yong-Jing Gao, Zhongping Chen, Faming Wang, Yan Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |