Rh(iii)-catalyzed oxidative C–H annulation of 6-arylpyridazin-3(2H)-ones: direct access to diarylpyridazino[6,1-a]isoquinolin-5-ium-3-olates
Chaitanya Ittamalla, N. S. S. Mukundram, Jyothirmai Nagireddy, B. Sridhar, B. V. Subba Reddy · 2026
Read Rh(iii)-catalyzed oxidative C–H annulation of 6-arylpyridazin-3(2H)-ones: direct access to diarylpyridazino[6,1-a]isoquinolin-5-ium-3-olates by Chaitanya Ittamalla, N. S. S. Mukundram, Jyothirmai Nagireddy, B. Sridhar, B. V. Subba Reddy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13185700.txt.
Description
Chaitanya Ittamalla and co-authors forge a fused nitrogen ring system in one catalytic step. Their twenty twenty-six paper uses a rhodium catalyst to stitch internal alkynes into aryl pyridazinones through carbon-hydrogen bond activation. The products are diaryl pyridazino-isoquinolin salts with a mesoionic core, shapes prized in drug hunting.
Yields run good across a spread of starting parts, and the method tolerates many side groups. This is the first ortho annulation of its kind on this ring family. Direct access to angular fused scaffolds skips long syntheses, handing medicinal chemists a fresh shelf of cores to dress for screening.
Catalog record
| CREATOR | Chaitanya Ittamalla, N. S. S. Mukundram, Jyothirmai Nagireddy, B. Sridhar, B. V. Subba Reddy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |