Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site
Irene van der Haar Àvila, Kristiaan Lenos, Victor Lorrain, Eleonora Nardini, Ernesto Rodríguez, Juan J García‐Vallejo, Yvette van Kooyk, Joep Grootjans, Sandra J van Vliet · 2026
Read Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site by Irene van der Haar Àvila, Kristiaan Lenos, Victor Lorrain, Eleonora Nardini, Ernesto Rodríguez, Juan J García‐Vallejo, Yvette van Kooyk, Joep Grootjans, Sandra J van Vliet (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13185675.txt.
Description
Irene van der Haar Àvila and eight co-authors report a 2026 study on sugar coats that shield colon cancer spread to the belly lining. Such spread carries a grim outlook. Tumors often wear extra sialic acid sugars, which act as checkpoints that calm immune attack, but their role at the belly site was unexplored.
Belly deposits wore more of the sugar than the first tumor or liver deposits did. Cancer cells stripped of the sugar, placed in mouse bellies, grew far less and scored lower on spread scales. Their tumors also drew more live immune cells, with more of the presenting kinds and fewer suppressive ones. The authors name the sugar coat a drug target for this spread site.
Catalog record
| CREATOR | Irene van der Haar Àvila, Kristiaan Lenos, Victor Lorrain, Eleonora Nardini, Ernesto Rodríguez, Juan J García‐Vallejo, Yvette van Kooyk, Joep Grootjans, Sandra J van Vliet |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |