RNA-based therapeutics for Alzheimer’s disease and related tauopathies: challenges and opportunities
Binita Rajbanshi, Ilaria Brentari, Michela Alessandra Denti, Jeffrey L Cummings, Anuj Guruacharya · 2026
Read RNA-based therapeutics for Alzheimer’s disease and related tauopathies: challenges and opportunities by Binita Rajbanshi, Ilaria Brentari, Michela Alessandra Denti, Jeffrey L Cummings, Anuj Guruacharya (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13185650.txt.
Description
Rajbanshi, Brentari, Denti, Cummings, and Guruacharya wrote a review in twenty twenty-six on RNA-based therapies for Alzheimer's disease and kin tau diseases. These diseases feature buildup of a protein called tau in the brain. Antibody and small-molecule drugs have failed in many trials so far. RNA therapies can target tau at its molecular source instead. The review surveys forms like messenger RNA, antisense strands, and splicing switches. Each form carries distinct promises for tau control. Shared hurdles include delivery to the brain and durability.
The authors outline molecular targets now in play. They track clinical trials and patent trends in the young field. Translational barriers get a full treatment in the review. The piece maps a nascent route to disease-modifying care.
Catalog record
| CREATOR | Binita Rajbanshi, Ilaria Brentari, Michela Alessandra Denti, Jeffrey L Cummings, Anuj Guruacharya |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |