Regulation of inflammation by omega-3 and omega-6 fatty acids: a meta-analysis of randomized trials
Zicheng Huang, Xiangjun Zhan, Jun Jin, Qingzhe Jin · 2026
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Description
Zicheng Huang, Xiangjun Zhan, Jun Jin, and Qingzhe Jin pooled randomized trials to compare how omega-3 and omega-6 fats affect inflammation, in a 2026 meta-analysis. Both fat families are often cast as rivals, one calming inflammation and the other feeding it, but trial evidence was scattered. The team searched six databases and found nine trials with five hundred and four participants, tracking four standard inflammatory markers.
Across all trials, supplements did not significantly move three of the markers: interleukin-6, C-reactive protein, or tumor necrosis factor alpha. One marker, interleukin-1 beta, did fall significantly, with the clearest drop in the omega-6 subgroup, which complicates the usual story. Omega-3 also failed to improve interleukin-6 in patients with fatty liver disease, and short courses changed little. The authors conclude that both fat families have limited effects on most markers, with omega-6 showing a specific benefit worth a closer look.
Catalog record
| CREATOR | Zicheng Huang, Xiangjun Zhan, Jun Jin, Qingzhe Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |