A novel regulatory role of microRNA-5590-3p in hepatocellular carcinoma via the HOXB2/MYC axis
Bin Li, Lin Zhou · 2026
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Description
Bin Li and Lin Zhou published this study in 2026. It examines a tiny RNA strand in liver cancer cells. The strand, called miR-5590-3p, is scarce in these tumors, while two growth-linked genes, HOXB2 and MYC, are unusually active.
Lab tests showed the RNA binds to HOXB2 and holds it down, and HOXB2 in turn switches MYC on. When the RNA was missing, cancer cells grew, moved, and invaded more, and fewer of them died. Adding the RNA back, or silencing HOXB2, reversed those effects. In mice, extra RNA slowed tumor growth. Patients with low RNA levels and high HOXB2 levels tended to fare worse. The authors present this chain as a possible target for future liver cancer drugs.
Catalog record
| CREATOR | Bin Li, Lin Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |