Cumulative evidence for associations between matrix metalloproteinase-1, -3 and -8 variants and cancer risk
Suqin Xu, Xianping Liu, Chenglu Huang · 2026
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Description
Suqin Xu, Xianping Liu, and Chenglu Huang pooled the world's evidence on three gene variants and cancer risk, in this 2026 paper. The genes make matrix metalloproteinases, enzymes that cut through tissue scaffolding. Inherited differences in these genes have been tied to cancer susceptibility in many small studies, with results that clash between populations and tumor types.
Combining the studies gave 36,368 cancer cases and 40,246 controls. Three variants stood out as truly linked to risk across seven cancer types. The authors graded the strength of the evidence using standard criteria plus a check on false-positive risk, and they split the results by ancestry, inheritance pattern, and cancer type. Two variants earned the grade of strong evidence for particular cancers, including one tied to cancer of the food pipe. The paper gives a firmer verdict on a crowded and contradictory literature.
Catalog record
| CREATOR | Suqin Xu, Xianping Liu, Chenglu Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |