Effect of the miR-26a/b-5p-STAT3-YKL-40 regulatory axis on proliferation, migration, and invasion of endometrial cancer cells
Xinzhao Sun, Shanshan Lin, Xueyan Zhong, Yanlu Luo, Jiahuang Yang, Jiangtao Fan · 2026
Read Effect of the miR-26a/b-5p-STAT3-YKL-40 regulatory axis on proliferation, migration, and invasion of endometrial cancer cells by Xinzhao Sun, Shanshan Lin, Xueyan Zhong, Yanlu Luo, Jiahuang Yang, Jiangtao Fan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13184815.txt.
Description
Xinzhao Sun and co-authors present a 2026 lab study of a gene control chain that drives endometrial cancer, a cancer of the womb lining whose rates rise each year. At the centre of the chain sits STAT3, a switch protein tied to tumour growth in many cancers. Two small RNA molecules can switch it off, and the switch in turn raises a partner protein called YKL-40.
Tests on tumour tissue showed high levels of the switch protein, linked to worse disease. In cancer cells, raising the switch boosted growth, movement, and invasion, undoing the brake applied by the small RNAs. Binding tests confirmed the switch raises its partner. The chain offers fresh targets for treatment.
Catalog record
| CREATOR | Xinzhao Sun, Shanshan Lin, Xueyan Zhong, Yanlu Luo, Jiahuang Yang, Jiangtao Fan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |