Macrolide resistance via 23S rRNA gene mutation in Corynebacterium ulcerans
Chiara Crestani, Sylvie Brémont, Marion Barbet, Kristina Museux, Edgar Badell, Sylvain Brisse · 2026
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Description
An animal-borne bacterium that can cause a diphtheria-like illness in people has turned up resistant to a front-line antibiotic family through a new route. Chiara Crestani and co-authors report the strain in this 2026 paper. It was isolated from the nose of a ten-year-old cat and could produce the diphtheria toxin.
Known resistance genes were absent. Instead, the resistance came from a mutation in the very gene the drugs target, a route not previously shown in this species. Until now, resistance in these bacteria was blamed on borrowed genes from other microbes. A homegrown mutation route changes surveillance: gene panels alone would miss it, so labs must also read the target gene itself when a strain tests resistant.
Catalog record
| CREATOR | Chiara Crestani, Sylvie Brémont, Marion Barbet, Kristina Museux, Edgar Badell, Sylvain Brisse |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |