DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis
Umar K Khan, Ayush Goel, Shivansh Nigam, Nazia Chaudhary, Ayush Praveen, Anjan Roy, Fabeha Fatima, Dilpreet K Sawhney, Afiya Dalwai, Akshay Shendre, Shannon Carskadon, Anjali Bajpai, Abhimanyu Kapoor, Anjali Tewari, Abhijit Chandra, Avanish Saklani, Sorab N Dalal, Nallasivam Palanisamy, Bushra Ateeq · 2026
Read DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis by Umar K Khan, Ayush Goel, Shivansh Nigam, Nazia Chaudhary, Ayush Praveen, Anjan Roy, Fabeha Fatima, Dilpreet K Sawhney, Afiya Dalwai, Akshay Shendre, Shannon Carskadon, Anjali Bajpai, Abhimanyu Kapoor, Anjali Tewari, Abhijit Chandra, Avanish Saklani, Sorab N Dalal, Nallasivam Palanisamy, Bushra Ateeq (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13184283.txt.
Description
Umar K Khan and co-authors study a gene called DKC1 that helps bowel cancer grow and resist drugs, in work published in 2026. The gene helps manage RNA changes and the caps on chromosome ends. High levels of the gene in tumours link to poor outcomes for patients.
The team shows the gene speeds cell growth, blocks cell death, and supports stem-like traits in cancer cells. A known growth pathway and the gene boost each other in a loop. The gene also disrupts fat-like molecules in cell membranes, which helps tumours resist a standard drug mix. In lab-grown tumour samples from patients, blocking the gene or its partner pathway restored drug response. The authors propose the gene as a drug target and its fat products as blood markers.
Catalog record
| CREATOR | Umar K Khan, Ayush Goel, Shivansh Nigam, Nazia Chaudhary, Ayush Praveen, Anjan Roy, Fabeha Fatima, Dilpreet K Sawhney, Afiya Dalwai, Akshay Shendre, Shannon Carskadon, Anjali Bajpai, Abhimanyu Kapoor, Anjali Tewari, Abhijit Chandra, Avanish Saklani, Sorab N Dalal, Nallasivam Palanisamy, Bushra Ateeq |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 120 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |