Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM
Mayu Yoshida, Felix Gersteuer, Ole Berendes, Keigo Fujiwara, Haaris A. Safdari, Helge Paternoga, Hiraku Takada, Nozomu Obana, Helmut Grubmüller, Lars V. Bock, Daniel N. Wilson, Shinobu Chiba · 2026
Read Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM by Mayu Yoshida, Felix Gersteuer, Ole Berendes, Keigo Fujiwara, Haaris A. Safdari, Helge Paternoga, Hiraku Takada, Nozomu Obana, Helmut Grubmüller, Lars V. Bock, Daniel N. Wilson, Shinobu Chiba (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13183943.txt.
Description
Mayu Yoshida and a large team uncover how a bacterial peptide stalls ribosomes. Arrest peptides pause protein synthesis in response to cell conditions, fine-tuning gene expression. The peptide CliM, found in Clostridia, sits upstream of the gene for YidC, a protein that inserts other proteins into membranes, suggesting it monitors YidC activity.
Two versions behave differently. One, from Clostridium kluyveri, halts the building stage at many codons, while the Clostridioides difficile version stops the ending stage instead. Structural work shows the second folds into helices inside the ribosome tunnel and blocks the entry of the next factor. Simulations suggest membrane insertion unwinds the helices and releases the arrest. One framework explains both behaviors.
Catalog record
| CREATOR | Mayu Yoshida, Felix Gersteuer, Ole Berendes, Keigo Fujiwara, Haaris A. Safdari, Helge Paternoga, Hiraku Takada, Nozomu Obana, Helmut Grubmüller, Lars V. Bock, Daniel N. Wilson, Shinobu Chiba |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 95 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |