Folate metabolism–based risk stratification identifies CYP27B1 as a determinant of tumor progression in HNSCC
Kai Zhang, Bingya Liu, Haixia Hu · 2026
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Description
Kai Zhang, Bingya Liu, and Haixia Hu build a folate based risk score for head and neck cancer in 2026. This cancer returns often and survival is poor. Folate pathways feed cell growth and may shape outlook. Gene data from a large atlas fed an eleven gene model. The score split patients into clear survival groups.
It stood as a risk factor on its own. High risk tumors showed fired up cancer paths and a muted immune scene. Drug response guesses pointed to harder chemo resistance there. One gene stood out in lab tests. Knocking it down curbed tumor traits and raised drug sensitivity. The authors pitch the score as a guide for risk and therapy.
Catalog record
| CREATOR | Kai Zhang, Bingya Liu, Haixia Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |