Organoids: From Bench to Bedside Applications
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu · 2026
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Description
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, and Xiaojuan Liu review organoids, lab-grown miniature tissues, with an eye on their path from bench to bedside. Grown from stem cells, organoids copy the structure and cell mix of real human tissues far better than flat cell cultures, and without the species gaps of animal models. The review focuses heavily on virus research.
Organoids have let scientists grow stubborn pathogens like human rhinovirus C and norovirus and have yielded new insight into how SARS-CoV-2 and Zika virus cause disease. They also serve as test beds for antiviral drugs before clinical trials. The authors extend the survey to cancer and brain disease modeling, compare cell sources, and discuss pairing organoids with gene editing and 3D bioprinting. Standing obstacles include missing immune components and poor blood-vessel growth. A stepwise translational path is proposed.
Catalog record
| CREATOR | Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 110 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |