Cardiac Electrophysiologic Effects of Different Local Anesthetics in Langendorff-Perfused Rabbit Hearts
Julian Wolfes, Amy Katthöfer, Felix Wegner, Benjamin Rath, Florian Doldi, Sati Güler-Eren, Lars Eckardt, Gerrit Frommeyer, Christian Ellermann · 2026
Read Cardiac Electrophysiologic Effects of Different Local Anesthetics in Langendorff-Perfused Rabbit Hearts by Julian Wolfes, Amy Katthöfer, Felix Wegner, Benjamin Rath, Florian Doldi, Sati Güler-Eren, Lars Eckardt, Gerrit Frommeyer, Christian Ellermann (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13183750.txt.
Description
Julian Wolfes and co-authors compare how different local anesthetics affect the heart's electrical system, in a 2026 study. Local anesthetics numb tissue by blocking sodium channels. The same action can disturb the heart in toxic doses. Each drug in the class differs in strength, timing, and side effects.
The team used isolated rabbit hearts kept alive by perfusion. Catheters inside and outside the heart recorded its electrical signals. Several anesthetics were applied and their effects compared head to head. Measures covered conduction speed and recovery patterns. Results show which agents perturb the heart most. Anesthesiologists gain data for safer drug choice. The model also helps screen new agents before human use.
Catalog record
| CREATOR | Julian Wolfes, Amy Katthöfer, Felix Wegner, Benjamin Rath, Florian Doldi, Sati Güler-Eren, Lars Eckardt, Gerrit Frommeyer, Christian Ellermann |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |