Evidence of the role of Midkine and Pleiotrophin in the pathogenesis of Familial Mediterranean Fever
Zeinab Y Abdallah, Ghada Nour Eldeen, Mona F Sokkar, Rania Fawzy Mahmoud abdelkawy, Randa S Lotfy, Shymaa H Hussein, Khaled Hamed, Hala T El-Bassyouni · 2026
Read Evidence of the role of Midkine and Pleiotrophin in the pathogenesis of Familial Mediterranean Fever by Zeinab Y Abdallah, Ghada Nour Eldeen, Mona F Sokkar, Rania Fawzy Mahmoud abdelkawy, Randa S Lotfy, Shymaa H Hussein, Khaled Hamed, Hala T El-Bassyouni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13183709.txt.
Description
Abdallah and seven colleagues test two cytokines as markers in familial Mediterranean fever in twenty twenty-six. The disease causes periodic inflammatory attacks with quiet inflammation between them. That hidden inflammation can damage organs over time. Midkine and pleiotrophin rise in many inflammatory conditions.
Blood from thirty patients and thirty controls was compared. Gene expression of both cytokines was higher in patients. Blood midkine levels were about four times the control level. Pleiotrophin ran higher too, but not significantly. Midkine expression tied inversely to a standard inflammation marker and positively to anaemia. The authors propose midkine as a tool for tracking hidden inflammation. Pleiotrophin may instead reflect acute flare activity.
Catalog record
| CREATOR | Zeinab Y Abdallah, Ghada Nour Eldeen, Mona F Sokkar, Rania Fawzy Mahmoud abdelkawy, Randa S Lotfy, Shymaa H Hussein, Khaled Hamed, Hala T El-Bassyouni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |