Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis
Qingyi Mao, Beibei Lin, Wenhao Xia, Yu Zhang, Yue Lei, Qian Cao, Mengque Xu · 2026
Read Melatonin-induced restoration of the intestinal mucosal barrier in inflammatory bowel disease via activation of the SIRT1-LKB1-pAMPK axis by Qingyi Mao, Beibei Lin, Wenhao Xia, Yu Zhang, Yue Lei, Qian Cao, Mengque Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13183551.txt.
Description
Seven authors report a 2026 study of melatonin, the hormone best known for sleep, and its effect on the gut wall in bowel disease. People with this disease often sleep poorly, and the team asked whether the hormone could help repair the gut lining.
Tests in patients, mice with colitis, and lab cells gave a linked set of results. Patients had low levels of the hormone, while treated mice had less gut harm and a healthier mix of gut germs. Lab work tied the benefit to a chain of proteins in gut cells, and drugs that blocked that chain removed the benefit. The findings point to a possible new treatment path.
Catalog record
| CREATOR | Qingyi Mao, Beibei Lin, Wenhao Xia, Yu Zhang, Yue Lei, Qian Cao, Mengque Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |