Large-scale cryptic proteome mining revealed potential phage-mediated host-pathogen genetic exchange in Mycobacterium tuberculosis
Nikhil Bhalla, Nupur Angrish, Swati Jaiswal, Swati Jaiswal, Swati Jaiswal · 2026
Read Large-scale cryptic proteome mining revealed potential phage-mediated host-pathogen genetic exchange in Mycobacterium tuberculosis by Nikhil Bhalla, Nupur Angrish, Swati Jaiswal, Swati Jaiswal, Swati Jaiswal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13183242.txt.
Description
Nikhil Bhalla, Nupur Angrish, and co-authors mine hidden proteins in tuberculosis bacteria in a 2026 study. Lab strains of the bacterium differ from strains found in patients, partly through new gene segments. Some of those segments may arrive through virus-like carriers that move genes between cells.
The team assembled genome data from countries where tuberculosis is common. A deep learning language model for proteins predicted which hidden segments could code for real proteins. Structure tools then checked the shapes and stability of the candidates. Most small hidden proteins came from a few known gene families. Signs of phage-linked exchange suggest one route by which the pathogen gains new traits.
Catalog record
| CREATOR | Nikhil Bhalla, Nupur Angrish, Swati Jaiswal, Swati Jaiswal, Swati Jaiswal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |