The association between two common levels of apolipoprotein and chronic obstructive pulmonary disease: A Mendelian randomized study
Chengqian Chen, Zhaobin Sun, Wentao Zhong, Hao Zheng, Zheng Zuo, Xin Zhang, Yushi Wang, Wei Zhao, Botao Shen · 2026
Read The association between two common levels of apolipoprotein and chronic obstructive pulmonary disease: A Mendelian randomized study by Chengqian Chen, Zhaobin Sun, Wentao Zhong, Hao Zheng, Zheng Zuo, Xin Zhang, Yushi Wang, Wei Zhao, Botao Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13183101.txt.
Description
Chengqian Chen, Zhaobin Sun, Wentao Zhong, and a team of co-authors use genetics to test whether two blood fats actually cause chronic lung disease, rather than merely travel with it. Reports had linked the carrier proteins ApoA-I and ApoB with COPD, but ordinary studies cannot separate cause from coincidence.
Borrowing nature's own experiment, they used gene variants that nudge each protein's level up or down and checked whether COPD risk follows. Higher ApoA-I, as set by the genes, came with a slightly lower risk of the disease, and the result held up after statistical checks and adjustments. ApoB showed no causal link at all. The authors present ApoA-I as the more plausible protective factor of the two.
Catalog record
| CREATOR | Chengqian Chen, Zhaobin Sun, Wentao Zhong, Hao Zheng, Zheng Zuo, Xin Zhang, Yushi Wang, Wei Zhao, Botao Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |