Regulation of mRNA decay and translation during the mammalian cell cycle
Jimmy Ly, Ekaterina Khalizeva, Yi Fei Tao, Iain M Cheeseman · 2026
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Description
Jimmy Ly and co-authors review how cells control the making and breaking of messenger RNA as they move through the cell cycle, in work from 2026. Dividing cells must remodel their gene activity at each stage, and attention has long focused on gene switching and protein changes.
The review argues that RNA decay and the control of protein production from RNA matter just as much. Across the cycle's phases, cells adjust both overall and gene-specific RNA stability to support DNA copying, growth, checkpoint signaling, and chromosome separation. During division itself, gene switching nearly stops, so cells depend on these RNA-level controls to keep working and stay alive.
Catalog record
| CREATOR | Jimmy Ly, Ekaterina Khalizeva, Yi Fei Tao, Iain M Cheeseman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |