Lipidated peptides and the limits of chemical control
Cesar Augusto Roque-Borda, Anamika Sharma, Fernando Rogério Pavan, Beatriz G. de la Torre, Fernando Albericio · 2026
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Description
Five chemists urge a more careful reading of what fat-tagging a peptide really proves. Attaching a lipid tail to a peptide often makes it look stronger in tests, since the tail helps it stick to membranes, ride on carrier proteins, and stay in the body longer. The authors argue that this apparent strength can mislead: the gain may come from delivery and exposure rather than from a better fit between the peptide and its target.
Standard measures, such as the lowest dose that stops bacterial growth, blend true activity with these distribution effects, so they cannot guide fine design choices alone. The authors do not oppose lipidation. They ask chemists to treat the fat tail as a controllable design element whose effects must be separated from the peptide's own action, so results stay interpretable and designs stay sound.
Catalog record
| CREATOR | Cesar Augusto Roque-Borda, Anamika Sharma, Fernando Rogério Pavan, Beatriz G. de la Torre, Fernando Albericio |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |