NOP56 Drives Colorectal Cancer Progression by Modulating p53 Acetylation through SIRT1/p300
Ji Eon Park, Chi-Hoon Ahn, Deok Yong Sim, Su-Yeon Park, Hyun Ju Cha, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim · 2026
Read NOP56 Drives Colorectal Cancer Progression by Modulating p53 Acetylation through SIRT1/p300 by Ji Eon Park, Chi-Hoon Ahn, Deok Yong Sim, Su-Yeon Park, Hyun Ju Cha, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13181856.txt.
Description
Park and co-authors identify a nucleolar protein that drives colorectal cancer growth in this 2026 study. The protein, NOP56, helps build the cell's protein factories. It had been tied to other cancers but not studied in colorectal tumors.
Tumor tissues carried far more NOP56 than nearby normal tissue, and high levels tracked with poor survival. Silencing the protein slowed cancer cell growth, colony formation, and migration, above all in cells with working p53. The silencing raised p53 levels and steadied it by curbing a removing enzyme. It also made the standard drug 5-fluorouracil kill more cells. In mouse grafts, tumors with silenced NOP56 grew much less.
Catalog record
| CREATOR | Ji Eon Park, Chi-Hoon Ahn, Deok Yong Sim, Su-Yeon Park, Hyun Ju Cha, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |