The NFIA::CBFA2T3 identifies a molecularly defined subgroup of acute erythroid leukemia/erythroid sarcoma
Marta Brunetti, Kristin Andersen, Geir Erland Tjønnfjord, Bernward Zeller, Signe Spetalen, Monica Cheng Munthe-Kaas, Liv Toril Nygård Osnes, Tina Treu Os, Francesca Micci · 2026
Read The NFIA::CBFA2T3 identifies a molecularly defined subgroup of acute erythroid leukemia/erythroid sarcoma by Marta Brunetti, Kristin Andersen, Geir Erland Tjønnfjord, Bernward Zeller, Signe Spetalen, Monica Cheng Munthe-Kaas, Liv Toril Nygård Osnes, Tina Treu Os, Francesca Micci (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13181429.txt.
Description
Marta Brunetti and co-authors report a rare blood cancer case in a 2026 paper about a two-year-old boy. His illness was an erythroid sarcoma, a tumor of young red blood cell precursors growing outside the bone marrow. It had spread widely, reaching the chest, gut, kidneys, and lymph nodes, which made diagnosis hard.
Standard leukemia-style treatment plus a stem cell transplant from a donor brought a lasting complete remission. Testing found a gene fusion joining NFIA and CBFA2T3 in the tumor. That fusion has appeared only in child cases of this leukemia family, so the authors propose it marks a distinct molecular subgroup. Naming such subgroups can sharpen diagnosis and guide care for future patients.
Catalog record
| CREATOR | Marta Brunetti, Kristin Andersen, Geir Erland Tjønnfjord, Bernward Zeller, Signe Spetalen, Monica Cheng Munthe-Kaas, Liv Toril Nygård Osnes, Tina Treu Os, Francesca Micci |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |