Small Molecule Inhibition of Mononegavirales RNA Polymerases
Claire R Cao, Meer Mohammed, Ge Yang, Dong Wang · 2026
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Description
Claire R. Cao, Meer Mohammed, Ge Yang, and Dong Wang wrote a 2026 review of drug design against a family of dangerous viruses. The group includes several major human pathogens whose copying machinery depends on one large working protein. New microscope images have recently revealed the shapes of these viral machines in fine detail.
The review sorts small-molecule drugs into two kinds: those that jam the machine's active copying site, and those that fit into side pockets and change its shape. Because these pockets look similar across related viruses, the authors argue that one drug might someday work against several family members at once.
Catalog record
| CREATOR | Claire R Cao, Meer Mohammed, Ge Yang, Dong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |