Structural insights into HRI kinase activity and inhibition
Min Cao, Glenn R. Masson · 2026
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Description
Min Cao and Glenn Masson review structural insights into the activity and inhibition of HRI kinase, a stress-sensing enzyme. Their 2026 review examines a protein emerging as a drug target in cancers and neurodegenerative disease.
HRI is one of four related kinases that switch off protein production by modifying a translation factor. It senses several proteotoxic stresses and prevents further rounds of protein synthesis. The review covers recent structural and molecular work on how the kinase activates and how inhibitors act. Regulatory interactions with other proteins and cofactors are also examined. Despite identification decades ago, the authors note surprisingly little is known about its regulation.
Catalog record
| CREATOR | Min Cao, Glenn R. Masson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |