circ-FSCN1 affects ferroptosis and cell viability in NSCLC via the miR-506-3p/SLC7A1 pathway
Wenxi Yu, Jiao Liu, Mingming Jin, Gang Huang, Qingqing Huang · 2026
Read circ-FSCN1 affects ferroptosis and cell viability in NSCLC via the miR-506-3p/SLC7A1 pathway by Wenxi Yu, Jiao Liu, Mingming Jin, Gang Huang, Qingqing Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13181243.txt.
Description
Wenxi Yu and four co-authors published a lung cancer study in twenty twenty-six on a circular RNA in tumor cells. Circ-FSCN1 helps the cells grow and dodge a fiery form of cell death. It was found at high levels in non-small cell lung cancer tissues and cell lines, and the team mapped its chain of action.
Silencing the circle slowed cell growth and migration and let reactive oxygen pile up, pushing ferroptosis. The circle normally sponges up a small RNA, miR-506-3p, which otherwise restrains a cystine transporter, SLC7A1. Restoring either downstream partner cancelled the silencing effects in two cell lines. Animal assays extended the story. The axis gives drug hunters three connected targets in one pathway.
Catalog record
| CREATOR | Wenxi Yu, Jiao Liu, Mingming Jin, Gang Huang, Qingqing Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |