In Vitro Effects of Cabazitaxel and Menadione on Cell Growth, Metabolism, and Transcriptomic Profile of Human Prostate Cancer Cell Lines
Ana Laura Gómez-Rosas, Mayel Chirinos, Nancy Noyola-Martínez, Mariana Segovia-Mendoza, Nayeli Torres-Ramírez, Sandra Romero-Córdoba, Lilia G Noriega, Mitzi García-Olivares, Fernando Larrea, David Barrera, Mohd Farhan · 2026
Read In Vitro Effects of Cabazitaxel and Menadione on Cell Growth, Metabolism, and Transcriptomic Profile of Human Prostate Cancer Cell Lines by Ana Laura Gómez-Rosas, Mayel Chirinos, Nancy Noyola-Martínez, Mariana Segovia-Mendoza, Nayeli Torres-Ramírez, Sandra Romero-Córdoba, Lilia G Noriega, Mitzi García-Olivares, Fernando Larrea, David Barrera, Mohd Farhan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13181216.txt.
Description
Ana Laura Gómez-Rosas and co-authors pair a chemotherapy drug with a vitamin K cousin against prostate cancer cells in this 2026 study. The drug, cabazitaxel, is a second-generation taxane used when earlier treatment fails. Vitamin K forms have shown their own anti-cancer hints, but the pair had never been tested together.
On two human prostate cancer lines, each agent alone slowed growth. Together they hit harder than either, a true synergy. The cells' energy systems answered differently by line, some leaning on burning fuel, others on sugar fermentation. Gene reading of one line showed the combination changed the most genes, touching oxygen-radical handling, steroid pathways, and immune signals. The authors present the pairing as a candidate worth animal testing, with the gene shifts as first clues to how it works.
Catalog record
| CREATOR | Ana Laura Gómez-Rosas, Mayel Chirinos, Nancy Noyola-Martínez, Mariana Segovia-Mendoza, Nayeli Torres-Ramírez, Sandra Romero-Córdoba, Lilia G Noriega, Mitzi García-Olivares, Fernando Larrea, David Barrera, Mohd Farhan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |