Inflammation‐Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity
Marie Frutoso, Emie Delmas, Rudolf Corty, Eleonore Bettacchioli, Divi Cornec, Sophie Hillion, Soizic Garaud · 2026
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Description
Marie Frutoso and co-authors review the lymphoid structures that inflammation builds inside organs, and propose a cleaner way to sort them. Their review appeared in 2026. These clusters of immune cells can mature into organized hubs with germinal centers, or stay looser. The authors separate the loose inflammatory kind from mature tertiary structures, while allowing a continuum between them. They trace both across autoimmunity, cancer, transplant, drug side effects, and aging.
The same structure can help or harm: driving self-attack in autoimmune disease, yet supporting tumor defense in cancer, or turning suppressive in some settings. Shape, stroma, and how long antigens persist decide the output. The authors say naming the states precisely is the first step to treating them deliberately.
Catalog record
| CREATOR | Marie Frutoso, Emie Delmas, Rudolf Corty, Eleonore Bettacchioli, Divi Cornec, Sophie Hillion, Soizic Garaud |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |