Dapagliflozin attenuates cisplatin-induced nephrotoxicity in rats through modulation of ROS/NF-κB, BCL2/Bax and PINK1/Parkin signaling pathways
Esraa K. Khallaf, Eman A. Ramadan, Mohey M. Elmazar, Marwa M. Safar · 2026
Read Dapagliflozin attenuates cisplatin-induced nephrotoxicity in rats through modulation of ROS/NF-κB, BCL2/Bax and PINK1/Parkin signaling pathways by Esraa K. Khallaf, Eman A. Ramadan, Mohey M. Elmazar, Marwa M. Safar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13180985.txt.
Description
Esraa Khallaf and co-authors test, in 2026, whether a diabetes drug can protect rat kidneys from a common chemotherapy drug. The cancer drug often damages kidneys, and the diabetes drug is known for kidney protection through several pathways. Its effect on a cell cleanup process in this setting was unclear.
Rats received the diabetes drug daily for two weeks, with one dose of the cancer drug midway. Treated rats showed less kidney tissue damage and lower injury markers. Harmful oxidation and inflammation fell, cell death eased, and the cleanup process was restored. The authors conclude the drug guards kidneys through these combined effects.
Catalog record
| CREATOR | Esraa K. Khallaf, Eman A. Ramadan, Mohey M. Elmazar, Marwa M. Safar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |