Urolithin A safeguards against diabetes-induced pathospermia and embryotoxicity in rats
Reza Haddadi-Salmasi, Ahmad Gharekhani, Ali Shalizar-Jalali, Gholamreza Najafi · 2026
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Description
Diabetes can quietly damage male fertility, from sperm quality to the embryos those sperm create. Reza Haddadi-Salmasi and co-authors tested a gut-made compound, urolithin A, in 2026 as a shield in diabetic rats. Forty mature males were split into a healthy group, a diabetic group, and three diabetic groups given rising doses of the compound for sixty days.
The compound protected in proportion to dose. Hormone levels, antioxidant balance in the testes, sperm count and motion, and DNA quality all held up better with treatment. Fertility in the body and in the dish improved, as did rates of embryos reaching later stages. The authors credit the compound's antioxidant strength and call it a promising guard for diabetic reproductive harm, in rats at least.
Catalog record
| CREATOR | Reza Haddadi-Salmasi, Ahmad Gharekhani, Ali Shalizar-Jalali, Gholamreza Najafi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |