Social isolation of aged mice drives dramatic release of inflammatory lipoxygenase-derived oxylipins
Mareike Wichmann-Costaganna, Raphaëlle Petit, Julia Lindner, Madlen Haase, Vivien Bachmann, Robert Klaus Hofstetter, Markus Werner, Christiane Frahm, Oliver Werz, Patrick Schädel · 2026
Read Social isolation of aged mice drives dramatic release of inflammatory lipoxygenase-derived oxylipins by Mareike Wichmann-Costaganna, Raphaëlle Petit, Julia Lindner, Madlen Haase, Vivien Bachmann, Robert Klaus Hofstetter, Markus Werner, Christiane Frahm, Oliver Werz, Patrick Schädel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179954.txt.
Description
Mareike Wichmann-Costaganna and nine co-authors found in 2026 that lonely old mice flood their organs with inflammatory fat signals. The signals, called oxylipins, steer inflammation and drift badly with age. Aged mice put through repeated social isolation were compared with grouped peers across seven organs and blood.
Isolation drove up a key alarm protein and sparked heavy output of one enzyme family's oxylipins, strongest in liver, lung, and spleen. Exercise was tested as a counterweight. The work gives loneliness a chemical fingerprint in the body, a step toward treating isolation as a medical risk, not just a sad one.
Catalog record
| CREATOR | Mareike Wichmann-Costaganna, Raphaëlle Petit, Julia Lindner, Madlen Haase, Vivien Bachmann, Robert Klaus Hofstetter, Markus Werner, Christiane Frahm, Oliver Werz, Patrick Schädel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |