Changes in serological, inflammatory, and serum protein electrophoretic markers during ongoing meglumine antimoniate plus allopurinol therapy in canine leishmaniosis
Jacobo Giner, Ana González, María Eugenia Lebrero, Pablo Quilez, David Guallar, Álex Gómez, Diana Marteles-Aragüés, Sergio Villanueva-Saz · 2026
Read Changes in serological, inflammatory, and serum protein electrophoretic markers during ongoing meglumine antimoniate plus allopurinol therapy in canine leishmaniosis by Jacobo Giner, Ana González, María Eugenia Lebrero, Pablo Quilez, David Guallar, Álex Gómez, Diana Marteles-Aragüés, Sergio Villanueva-Saz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179883.txt.
Description
Giner, González, Lebrero and colleagues followed dogs with leishmaniosis through the first month of standard drug treatment in 2026. Eighteen dogs with confirmed disease started therapy with meglumine antimoniate plus allopurinol, and fifteen completed visits on days 0, 7, 14, 21 and 29.
Antibody levels fell during treatment on both ELISA methods, with the serial dilution test separating highly positive samples better. C-reactive protein dropped by day 29, showing less inflammation. Serum protein patterns also improved, with albumin and the albumin to globulin ratio rising and gamma globulins falling. The team presents these tests as practical tools for early checks of treatment response.
Catalog record
| CREATOR | Jacobo Giner, Ana González, María Eugenia Lebrero, Pablo Quilez, David Guallar, Álex Gómez, Diana Marteles-Aragüés, Sergio Villanueva-Saz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |