Effect of Perioperative Ketamine on Early Postpartum Depressive Symptoms Following Cesarean Section: A Meta-Analysis
Samantha Siu, Peter Hsin, Sarah Simon, Talia Lall, Anabel Lin, Da Young Lee, Rose Berkun, Patricia Junquera · 2026
Read Effect of Perioperative Ketamine on Early Postpartum Depressive Symptoms Following Cesarean Section: A Meta-Analysis by Samantha Siu, Peter Hsin, Sarah Simon, Talia Lall, Anabel Lin, Da Young Lee, Rose Berkun, Patricia Junquera (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179825.txt.
Description
Samantha Siu, Peter Hsin, and Sarah Simon lead a team pooling trials of ketamine given around cesarean delivery to blunt early postpartum depression. Their meta-analysis appeared in two thousand twenty-six. Depression after birth harms mothers and infants alike. Cesarean births carry higher rates, which makes the operating window tempting for prevention.
Six randomized trials from the last decade met their criteria. Mothers who received ketamine or its cousin esketamine scored lower on a standard depression scale in the first two weeks. The pooled benefit was modest and consistent in direction. Variation between trials was moderate. Dosing and timing remain unsettled, and long-term effects are unknown. The authors call for larger trials before routine use. Still, a drug already in the anesthesia kit may double as early mood protection.
Catalog record
| CREATOR | Samantha Siu, Peter Hsin, Sarah Simon, Talia Lall, Anabel Lin, Da Young Lee, Rose Berkun, Patricia Junquera |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |