SARS-CoV-2 membrane protein recruits PP2A to dephosphorylate the nucleocapsid and promote virion production
Sheng-Han Wang, Tai-Ling Chao, Chi-Ling Hsieh, Pei-Jer Chen, Sui-Yuan Chang, Shiou-Hwei Yeh · 2026
Read SARS-CoV-2 membrane protein recruits PP2A to dephosphorylate the nucleocapsid and promote virion production by Sheng-Han Wang, Tai-Ling Chao, Chi-Ling Hsieh, Pei-Jer Chen, Sui-Yuan Chang, Shiou-Hwei Yeh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179615.txt.
Description
Sheng-Han Wang and co-authors traced a step in the life of the COVID-19 virus in a 2026 study. The virus wraps its genome in a shell protein whose tags must switch state as new virus parts form. Fresh shell protein carries many tags, while the protein packed in finished virus carries few, and the switch is needed for good output.
The team showed that the virus's membrane protein brings in a host enzyme crew that strips those tags off. That stripping helps the virus turn out more finished copies. Past work on kin viruses hinted at the same switch. The finding names a host crew the virus leans on, which could be a drug target.
Catalog record
| CREATOR | Sheng-Han Wang, Tai-Ling Chao, Chi-Ling Hsieh, Pei-Jer Chen, Sui-Yuan Chang, Shiou-Hwei Yeh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |