Glutamate dehydrogenases in fungi: From biology to biotechnology
Ejaj K. Pathan, Himal Sapkota, Subrata Dasgupta, Narayan S. Punekar · 2026
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Description
Ejaj Pathan and co-authors review a family of enzymes at the heart of nitrogen handling in fungi. Their review from 2026 covers glutamate dehydrogenases, which swap a key building block back and forth with glutamate. The enzymes sit where ammonia uptake meets glutamate breakdown in fungal cells.
Two forms use unlike helper molecules, and they differ across fungi in place, control, and traits. Controls range from chemical tags to shape based switches. Solved shapes for the enzymes from three fungi show how helpers and targets bind. Gene paths for the two forms split in their history. Shape shifts in fungi, such as the yeast to thread switch, tie to these enzymes, which makes them drug target candidates.
Catalog record
| CREATOR | Ejaj K. Pathan, Himal Sapkota, Subrata Dasgupta, Narayan S. Punekar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |