Probing transcription factor subsets in gene regulatory networks
Lukas Geis, Dennis Hecker, Martin Hoefer, Ulrich Meyer, Marcel H Schulz · 2026
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Description
Lukas Geis, Dennis Hecker, Martin Hoefer, Ulrich Meyer, and Marcel Schulz study how to pick the set of transcription factors with the greatest sway over a target gene set. Transcription factors are the switches of genes. Such choices matter when scientists perturb cells and want the strongest, clearest effect. In the network view, switches and genes form a two-sided graph of influences.
The authors frame the search as a probing problem. A researcher tests some switches, learns from the outcome, and chooses the next probes wisely. They compare adaptive strategies, which react to results, with fixed ones on simulated networks. Then they run the methods on real data for genes in T-cell immunity. The work links computer science with gene regulation planning.
Catalog record
| CREATOR | Lukas Geis, Dennis Hecker, Martin Hoefer, Ulrich Meyer, Marcel H Schulz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |