Prenatal Methyl Nutrient Availability Shapes Mesolimbic Dopaminergic Circuitry and Systemic Inflammation in Wistar Rat Offspring of Both Sexes
Cassia Di Pierdomenico, William J. J. Cook, Jianzhang Dong, Gia V. Shelp, Elizabeth M. Poole, Sarah E. Burns, Clara E. Cho · 2026
Read Prenatal Methyl Nutrient Availability Shapes Mesolimbic Dopaminergic Circuitry and Systemic Inflammation in Wistar Rat Offspring of Both Sexes by Cassia Di Pierdomenico, William J. J. Cook, Jianzhang Dong, Gia V. Shelp, Elizabeth M. Poole, Sarah E. Burns, Clara E. Cho (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179531.txt.
Description
Cassia Di Pierdomenico and co-authors ask how a mother's methyl nutrients during pregnancy shape her pups' reward circuitry and inflammation. Folate, choline, and betaine feed the body's methylation system, which tunes genes and brain development. Earlier work showed that imbalance between folic acid and choline in pregnancy yields heavier rat offspring with disturbed methylation.
In Wistar rats, the team varies those nutrients and tests whether betaine, a direct methyl donor, can offset the effects. They track dopamine receptor expression in the reward system and body-wide inflammation, in male and female pups alike. The results speak to how prenatal diets program the brain's reward wiring.
Catalog record
| CREATOR | Cassia Di Pierdomenico, William J. J. Cook, Jianzhang Dong, Gia V. Shelp, Elizabeth M. Poole, Sarah E. Burns, Clara E. Cho |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |