ARMS‐qPCR‐Based Detection of BRAF and TERT Promoter Mutations: A Cost‐Effective Strategy for Molecular Diagnosis of Papillary Thyroid Carcinoma
Yuanyuan Jia, Yajun Zhang, Dandan Sun, Jiabao Yang, Mengshi Zhou, Min Gao, Rui Li · 2026
Read ARMS‐qPCR‐Based Detection of BRAF and TERT Promoter Mutations: A Cost‐Effective Strategy for Molecular Diagnosis of Papillary Thyroid Carcinoma by Yuanyuan Jia, Yajun Zhang, Dandan Sun, Jiabao Yang, Mengshi Zhou, Min Gao, Rui Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179447.txt.
Description
Yuanyuan Jia and co-authors build a cheap gene test for thyroid cancer in a 2026 paper. Papillary thyroid cancer often carries a change in the BRAF gene or in a gene switch called TERT, and finding them aids diagnosis. Standard sequencing is slow and costly for many clinics.
Their method pairs a mutation-specific amplification trick with glowing probes to catch three named changes in one workflow. In lab checks it beat commercial kits on accuracy and sensitivity. On 40 stored tissue samples, it found the BRAF change in more than four of five cancers, matching sequencing where it counted. Fast, cheap mutation checks could widen molecular diagnosis.
Catalog record
| CREATOR | Yuanyuan Jia, Yajun Zhang, Dandan Sun, Jiabao Yang, Mengshi Zhou, Min Gao, Rui Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |