Superparamagnetic iron oxide nanoparticle-driven 3-aroyl-1,4-diarylpyrrole nanocomposites (ARDAP@SPION-PEI) mediate renal cancer cell PANoptosis by regulating chromatin accessibility
Hongliang Shen, Zeyu Cui, Yilun Wu, Michela Puxeddu, Yanchen Lai, Ren Mo, Boyu Yang, Yinong Niu, Yichao Wen, Xiling Du, Romano Silvestri, Te Liu · 2026
Read Superparamagnetic iron oxide nanoparticle-driven 3-aroyl-1,4-diarylpyrrole nanocomposites (ARDAP@SPION-PEI) mediate renal cancer cell PANoptosis by regulating chromatin accessibility by Hongliang Shen, Zeyu Cui, Yilun Wu, Michela Puxeddu, Yanchen Lai, Ren Mo, Boyu Yang, Yinong Niu, Yichao Wen, Xiling Du, Romano Silvestri, Te Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179415.txt.
Description
Hongliang Shen and co-authors present a 2026 study of a new drug package against kidney cancer stem cells. These stem-like cells grow fast, resist standard care, and seed new tumors. The team's drug blocks cell scaffolding but dissolves poorly in water, so little of it reaches its target. They loaded the drug onto tiny iron-based grains coated to carry it.
In lab and animal tests, the loaded grains slowed the stem cells' growth and spread. Treated fish embryos grew fewer new blood vessels near tumors. The treatment switched on genes of a mixed cell-death pathway and widened access to parts of the cell's DNA. One switch protein stood out and turned the death genes on. The work shows a way to make a hard-to-use drug reach the cells that drive relapse.
Catalog record
| CREATOR | Hongliang Shen, Zeyu Cui, Yilun Wu, Michela Puxeddu, Yanchen Lai, Ren Mo, Boyu Yang, Yinong Niu, Yichao Wen, Xiling Du, Romano Silvestri, Te Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |