CD19/BCMA‐Targeted Chimeric Antigen Receptor‐T Cell Therapy for Anti‐HLA Antibody Sensitisation in Patients With Acute Leukaemia: A Pilot Clinical Study
Haiqiong Zheng, Houli Zhao, Xinyi Zhu, Jingjing Feng, Guoqing Wei, Shi Han, Simao Huang, Jiazhen Cui, Shan Fu, Mingming Zhang, Yanlei Zhang, Jimin Shi, Yi Luo, Alex H Chang, Yongxian Hu, He Huang · 2026
Read CD19/BCMA‐Targeted Chimeric Antigen Receptor‐T Cell Therapy for Anti‐HLA Antibody Sensitisation in Patients With Acute Leukaemia: A Pilot Clinical Study by Haiqiong Zheng, Houli Zhao, Xinyi Zhu, Jingjing Feng, Guoqing Wei, Shi Han, Simao Huang, Jiazhen Cui, Shan Fu, Mingming Zhang, Yanlei Zhang, Jimin Shi, Yi Luo, Alex H Chang, Yongxian Hu, He Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179401.txt.
Description
Haiqiong Zheng and colleagues piloted a cell therapy in 2026 for transplant readiness. Some leukemia patients carry antibodies against donor tissue markers. Those antibodies can block or endanger a transplant. Current methods to lower them often fall short. The team tested engineered immune cells that hunt antibody-making cells. The cells targeted one of two markers on those producers. Seven patients with acute leukemia joined the single-arm pilot. Most got one cell type, and one got the other.
No severe brain side effects appeared. No severe storm-like immune reactions appeared either. The engineered cells grew in most patients after infusion. Antibody levels fell in most patients with starting antibodies. A few patients saw large drops. Donor-specific antibody levels fell where they were tracked. Two patients reached transplant after added preparation. The authors call the approach promising but early. Larger studies must confirm safety and benefit, they stress.
Catalog record
| CREATOR | Haiqiong Zheng, Houli Zhao, Xinyi Zhu, Jingjing Feng, Guoqing Wei, Shi Han, Simao Huang, Jiazhen Cui, Shan Fu, Mingming Zhang, Yanlei Zhang, Jimin Shi, Yi Luo, Alex H Chang, Yongxian Hu, He Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |