VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis
Hans Schoofs, Yan Zhang, Henrik Ortsäter, Mariya Lytvyn, Rui Benedito, Taija Mäkinen · 2026
Read VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis by Hans Schoofs, Yan Zhang, Henrik Ortsäter, Mariya Lytvyn, Rui Benedito, Taija Mäkinen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179370.txt.
Description
Hans Schoofs and co-authors find that a second receptor, VEGFR2, is required for lymphatic vessel sprouting driven by the growth signal VEGF-C through its main receptor VEGFR3. Lymphatic vessels maintain tissue balance and drain fluid, and their growth is led by that signal. Precise gene tools let the team switch receptors off in set cells and at set times. Their 2026 study asks how growth splits into two acts: making more cells, or sending out new sprouts.
Activating the second receptor alone could not start vessel growth. Delete it, and sprouting died in response to the signal, yet cell proliferation held. Delete a shared downstream effector, PI3Kα, and all lymphangiogenesis died. The two receptors sit near each other in lymphatic cells, and the effector steers how much of each rides the cell surface. More signal tilts the mix toward the second receptor, priming cells for sprouting.
Catalog record
| CREATOR | Hans Schoofs, Yan Zhang, Henrik Ortsäter, Mariya Lytvyn, Rui Benedito, Taija Mäkinen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |