Aging promotes a RAGE-dependent increase in breast cancer metastasis
Philip Miller, Sunita Chopra, Melinda Magna, Jiaxiang Tao, Carlos Benitez, Thomas Heist, Nanette H. Bishopric, Jeanne S. Mandelblatt, Julia Panov, Joyce M. Slingerland, Barry I. Hudson · 2026
Read Aging promotes a RAGE-dependent increase in breast cancer metastasis by Philip Miller, Sunita Chopra, Melinda Magna, Jiaxiang Tao, Carlos Benitez, Thomas Heist, Nanette H. Bishopric, Jeanne S. Mandelblatt, Julia Panov, Joyce M. Slingerland, Barry I. Hudson (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13179327.txt.
Description
Philip Miller and co-authors show that aging raises the spread of breast cancer in mice, and that the effect depends on a receptor called RAGE, in a 2026 study. Breast cancer rates and deaths rise with age, but how aging drives spread was unclear. Most lab studies use young animals, which limits insight.
In several mouse models, older hosts saw markedly more spread. Tumors in aged hosts carried higher levels of RAGE triggers and showed gene shifts tied to inflammation and vessel growth. Fluids from aged hosts made tumor cells invade more, an effect blocked by cutting RAGE. In human tumors, high RAGE gene activity linked to poorer survival.
Catalog record
| CREATOR | Philip Miller, Sunita Chopra, Melinda Magna, Jiaxiang Tao, Carlos Benitez, Thomas Heist, Nanette H. Bishopric, Jeanne S. Mandelblatt, Julia Panov, Joyce M. Slingerland, Barry I. Hudson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |