Large Vessel Vasculitis: Recent Advances in Pathophysiology and Targeted Therapies
Myriam Reisch, Jens Thiel, Philipp Bosch · 2026
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Description
Myriam Reisch, Jens Thiel, and Philipp Bosch present a 2026 review of large vessel vasculitis, a group of diseases that inflame the biggest arteries. The group includes giant cell arteritis and Takayasu arteritis. They share artery inflammation but differ in age of onset and in the immune paths that drive them.
The review sums up fresh genetic and molecular clues for each disease. It also covers shared drivers, such as interleukin-6 signaling and T-cell and macrophage invasion of the artery wall. New targeted drugs are then weighed against this biology. Blockers of the interleukin-6 receptor work well in giant cell arteritis, though some patients do not respond. A gene variant can even predict that weak response. The authors chart where therapy is heading.
Catalog record
| CREATOR | Myriam Reisch, Jens Thiel, Philipp Bosch |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |