DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High‐Grade Serous Ovarian Carcinoma
Ryosuke Uekusa, Akira Yokoi, Mayu Ukai, Kosuke Yoshida, Kunanon Chattrairat, Takao Yasui, Yasuhide Inokuma, Masami Kitagawa, Eri Asano‐Inami, Masato Yoshihara, Satoshi Tamauchi, Nobuhisa Yoshikawa, Kaoru Niimi, Juntaro Matsuzaki, Takahiro Ochiya, Anil K Sood, Yusuke Yamamoto, Hiroaki Kajiyama · 2026
Read DNA Copy Number Profiling in Extracellular Vesicles as Clinical Biomarkers of High‐Grade Serous Ovarian Carcinoma by Ryosuke Uekusa, Akira Yokoi, Mayu Ukai, Kosuke Yoshida, Kunanon Chattrairat, Takao Yasui, Yasuhide Inokuma, Masami Kitagawa, Eri Asano‐Inami, Masato Yoshihara, Satoshi Tamauchi, Nobuhisa Yoshikawa, Kaoru Niimi, Juntaro Matsuzaki, Takahiro Ochiya, Anil K Sood, Yusuke Yamamoto, Hiroaki Kajiyama (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13178793.txt.
Description
Ryosuke Uekusa and co-authors test whether DNA in tiny sacs shed by ovarian tumors can mark disease and drug response, in a study from 2026. The cancer type in focus is the most common form of ovarian cancer and is marked by broad gains and losses of DNA chunks. Sacs in body fluids carry that DNA, so the team read chunk counts in sac DNA from belly fluid and blood.
Sac DNA in belly fluid matched tumor DNA chunk for chunk far better than loose DNA did. Sick fluid held far more sac DNA than fluid from benign growths, even when cell checks were clean. Chunk maps split patients who shrank on a key drug from those who did not. A five gene score foretold drug response with strong skill.
Catalog record
| CREATOR | Ryosuke Uekusa, Akira Yokoi, Mayu Ukai, Kosuke Yoshida, Kunanon Chattrairat, Takao Yasui, Yasuhide Inokuma, Masami Kitagawa, Eri Asano‐Inami, Masato Yoshihara, Satoshi Tamauchi, Nobuhisa Yoshikawa, Kaoru Niimi, Juntaro Matsuzaki, Takahiro Ochiya, Anil K Sood, Yusuke Yamamoto, Hiroaki Kajiyama |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |