NaV1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn
Stephanie Shiers, Nwasinachi A Ezeji, Carla Lima‐Truax, Jeffrey L Krajewski, Geoffrey Funk, Anna Cervantes, Peter Horton, Gregory Dussor, Stephanie Hennen, Theodore J Price · 2026
Read NaV1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn by Stephanie Shiers, Nwasinachi A Ezeji, Carla Lima‐Truax, Jeffrey L Krajewski, Geoffrey Funk, Anna Cervantes, Peter Horton, Gregory Dussor, Stephanie Hennen, Theodore J Price (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13178720.txt.
Description
Stephanie Shiers and co-authors map a pain-linked channel in the human spinal cord in a 2026 study. The channel, called NaV1.7, carries signals in pain pathways, and human genetics marks it as a strong drug target. Drugs against it have disappointed in trials, partly due to heart side effects. Recent rodent work hinted that blocking it in the spinal cord might still ease pain, so the team checked where it sits in humans.
Gene messages for the channel appeared in output neurons of the upper dorsal horn and in deep horn cells. They also showed up in motor neurons and in cells lining the cord's central canal. The protein itself sat mostly in incoming sensory fibers, plus some motor cell bodies. The map guides where a cord-targeted drug could act.
Catalog record
| CREATOR | Stephanie Shiers, Nwasinachi A Ezeji, Carla Lima‐Truax, Jeffrey L Krajewski, Geoffrey Funk, Anna Cervantes, Peter Horton, Gregory Dussor, Stephanie Hennen, Theodore J Price |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |